Such a methodical approach as explained above by Michael is golden. However,  unfortunately the normal or general approach to use of substances is done according to societal norms or tendencies to sensual gratification or simply put, party mode.

For a seeker, the attitude is that of a psychonaut or one who is making an attempt at inner discovery and exploration. I find the questions suggested by Rishi to ponder upon during the experiences invaluable, as they provide not only an anchor but a direction within the trip in every sense of the words.

It should also be added that with the readoption of psychedelic substances in therapeutic practice, they are now commonly produced in controlled settings  where they are bred for different objectives to include higher potencies or very pure pharmaceutical grades that are not according to nature ordinary tendency to mitigate and balance the different organic components. 

But in my opinion it is more critical to consider one’s mind set at the time of indulgence or partaking. These substances depending on their nature or characteristics will invariably tend to allow the individual to access layers of their subconscious or subtle body (repository of instincts) as well as experiences related to other dimensions or realities that would not otherwise be accessed through the same individual’s field sensorial perceptions.

Therefore, just as in meditation when not sufficiently prepared for the mind will mostly access experiences and realities that are of personal preoccupation, experiences under influence can also tend to take one in directions that are directly related to one’s state of mind or psychological dispositions.

For some individuals, such experiences can become the onset of a psychotic breakdown when they are already constitutionally or genetically predisposed to, say schizophrenia or other psychological troubles. It is also easy to have a bad episode or trip based on the type of energy that is lingering within, for instance it is a bad idea to partake as a means to escape some stressful realities one is faced with. Setting the stage properly for exploration is of great importance and shows respect and consideration for the substance(s), as they can impact consciousness.

A not so great an illustration: